Lack of the PAC1 receptor alters the circadian expression of VIP mRNA in the suprachiasmatic nucleus of mice

Birgitte Georg; Jens Hannibal; Jan Fahrenkrug

doi:10.1016/j.brainres.2006.12.001

Lack of the PAC1 receptor alters the circadian expression of VIP mRNA in the suprachiasmatic nucleus of mice

Brain Res. 2007 Mar 2;1135(1):52-7. doi: 10.1016/j.brainres.2006.12.001. Epub 2006 Dec 28.

Authors

Birgitte Georg¹, Jens Hannibal, Jan Fahrenkrug

Affiliation

¹ Department of Clinical Biochemistry, Bispebjerg University Hospital, DK-2400 Copenhagen NV, Denmark. bg06@bbh.hosp.dk

PMID: 17196185
DOI: 10.1016/j.brainres.2006.12.001

Abstract

PACAP in the retinohypothalamic tract mediates photic information to the suprachiasmatic nucleus via the PAC1 receptor. The diurnal and circadian VIP mRNA expressions in the suprachiasmatic nucleus of PAC1-/- and wild type mice were quantified. During light/dark cycles identical VIP mRNA rhythms were found while the oscillation pattern differed between the two types of animals during constant darkness. The results show that the circadian VIP mRNA expression is influenced by the absence of PAC1 signalling.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Circadian Rhythm / genetics*
Female
Gene Expression Regulation / genetics*
Male
Mice
Mice, Knockout
RNA, Messenger / metabolism
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I / deficiency*
Suprachiasmatic Nucleus / metabolism*
Vasoactive Intestinal Peptide / genetics
Vasoactive Intestinal Peptide / metabolism*

Substances

RNA, Messenger
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
Vasoactive Intestinal Peptide