A 10-month-old girl was admitted with refractory infantile spasms. Video EEG demonstrated focal epileptic activity, and MRI revealed a conglomeration of annular lesions. Surgical excision was performed and pathology was consistent with tuberculoma. After antituberculous therapy, the outcome was favorable. Despite all investigations, Mycobacterium tuberculosis's mode of transmission was unclear, and both congenital and postnatal acquired forms were considered.