Abstract
A new triterpene glycoside, hillaside C (1), was isolated from the sea cucumber Holothuria hilla Lesson, which is found in the South China Sea, and its structure has been elucidated by spectral analysis (ESI-MS and NMR) and chemical transformations. Four known compounds, holothuria A, thymine, uracil, and cholesterol, were also obtained. Compound 1 exhibited significant cytotoxicity against eight human tumor cell lines (A-549, MCF-7, IA9, CAKI-1, PC-3, KB, KB-VIN, and HCT-8) with IC50 values in the range of 0.15-3.20 microg/ml.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cholesterol / chemistry
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Drug Screening Assays, Antitumor
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Glycosides / chemistry*
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Glycosides / pharmacology
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Models, Chemical
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Sea Cucumbers
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Spectrometry, Mass, Electrospray Ionization
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Thymine / chemistry
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Triterpenes / chemistry*
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Triterpenes / pharmacology
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Uracil / chemistry
Substances
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Antineoplastic Agents
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Glycosides
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Triterpenes
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hillaside C
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Uracil
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Cholesterol
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Thymine