Abstract
Three new C(21)-steroidal glycosides stemucronatosides H, I, and J (1-3, resp.) were isolated from the stems of Stephanotis mucronata, together with three known compounds sinomarinoside A (4), sinomarinoside E (5), and stephanoside H (6). These isolated compounds were tested for their immunological activities in vitro against concanavalin-A(Con A)- and lipopolysaccharide(LPS)-induced proliferation of mice splenocytes. Compounds 3, 4, and 6 showed immunosuppressive activities in a dose-dependent manner, while compounds 1, 2, and 5 possessed immunoenhancing activities.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cells, Cultured
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Immunologic Factors / chemistry
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Immunologic Factors / isolation & purification*
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Immunologic Factors / pharmacology
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Mice
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Phytosterols / chemistry
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Phytosterols / isolation & purification*
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Phytosterols / pharmacology
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Stems*
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Spleen / cytology
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Spleen / drug effects
Substances
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Glycosides
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Immunologic Factors
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Phytosterols
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Plant Extracts