Abstract
Monascin (1) constitutes one of the azaphilonoid pigments in the extracts of Monascus pilosus-fermented rice (red-mold rice). Compound 1 was evaluated for its anti-tumor-initiating activity via oral administration on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) or by ultraviolet light B (UVB) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Compound 1 exhibited marked inhibitory activity on both PN- and UVB-induced mouse skin carcinogenesis tests. These findings suggest that compound 1 may be valuable as potential cancer chemopreventive agent in chemical and environmental carcinogenesis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology*
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Female
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Heterocyclic Compounds, 3-Ring / chemistry*
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Heterocyclic Compounds, 3-Ring / metabolism
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Heterocyclic Compounds, 3-Ring / pharmacology*
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Mice
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Mice, Inbred SENCAR
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Molecular Structure
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Monascus / metabolism*
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Oryza / metabolism*
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Oryza / microbiology*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Skin Neoplasms / chemically induced
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Skin Neoplasms / pathology*
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Specific Pathogen-Free Organisms
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Time Factors
Substances
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Antineoplastic Agents
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Heterocyclic Compounds, 3-Ring
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Plant Extracts
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monascin