Sulfated alkenes from the echinus Temnopleurus hardwickii

Li Chen; Yuchun Fang; Xiaodong Luo; Hongping He; Tianjiao Zhu; Hongbing Liu; Qianqun Gu; Weiming Zhu

doi:10.1021/np058124i

Sulfated alkenes from the echinus Temnopleurus hardwickii

J Nat Prod. 2006 Dec;69(12):1787-9. doi: 10.1021/np058124i.

Authors

Li Chen¹, Yuchun Fang, Xiaodong Luo, Hongping He, Tianjiao Zhu, Hongbing Liu, Qianqun Gu, Weiming Zhu

Affiliation

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, People's Republic of China.

PMID: 17190460
DOI: 10.1021/np058124i

Abstract

Three new sulfated alkenes (1-3), trimethylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate, dimethylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate, and 2'-methyl-4'-oxobutan-2-ylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate, were isolated from an echinoderm, Temnopleurus hardwickii. Their structures were elucidated by spectral analysis and chemical degradation methods.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkenes / chemistry
Alkenes / isolation & purification*
Alkenes / pharmacology
Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
China
Drug Screening Assays, Antitumor
Echinodermata / chemistry*
Humans
Inhibitory Concentration 50
Leukemia P388
Mice
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Sulfuric Acid Esters / chemistry
Sulfuric Acid Esters / isolation & purification*
Sulfuric Acid Esters / pharmacology

Substances

2'-methyl-4'-oxobutan-2-ylammonium(5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate
Alkenes
Antineoplastic Agents
Sulfuric Acid Esters
dimethylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate
trimethylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate