DNA damage signaling recruits the RNA polymerase II binding protein Che-1 to the p53 promoter

Mol Cell. 2006 Dec 28;24(6):809-10. doi: 10.1016/j.molcel.2006.12.004.

Abstract

New work by Bruno et al. (2006) describes a mechanistic switch of the proliferation-promoting Che-1 activator of E2F-target genes into a cell-cycle inhibitor in response to DNA damage, through Che-1 relocalization to, and activation of, the p53 tumor suppressor gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis Regulatory Proteins / metabolism*
  • Carrier Proteins / metabolism*
  • Cyclin-Dependent Kinase Inhibitor p21 / metabolism
  • DNA Damage*
  • Humans
  • Models, Biological
  • Phosphoproteins / metabolism*
  • Promoter Regions, Genetic*
  • Repressor Proteins / metabolism*
  • Signal Transduction
  • Transcription Factors / metabolism*
  • Tumor Suppressor Protein p53 / genetics*

Substances

  • AATF protein, human
  • Apoptosis Regulatory Proteins
  • CDKN1A protein, human
  • Carrier Proteins
  • Cyclin-Dependent Kinase Inhibitor p21
  • Phosphoproteins
  • RNA polymerase II-binding proteins
  • Repressor Proteins
  • Transcription Factors
  • Tumor Suppressor Protein p53