Grabbing Plk1 by the PBD

Wei Dai; Xiaoxing Wang

doi:10.1016/j.molcel.2006.11.004

Grabbing Plk1 by the PBD

Mol Cell. 2006 Nov 17;24(4):489-90. doi: 10.1016/j.molcel.2006.11.004.

Authors

Wei Dai¹, Xiaoxing Wang

Affiliation

¹ Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA.

PMID: 17188028
DOI: 10.1016/j.molcel.2006.11.004

Abstract

A new centromeric protein termed PBIP1 was identified that recruits Plk1 to the kinetochores. In the November 3 issue of Molecular Cell, show that Plk1 phosphorylates PBIP1 on threonine 78, creating its own high-affinity docking site for the polo-box domain (PBD).

Publication types

Review
Comment

MeSH terms

Cell Cycle Proteins / metabolism*
Centromere / metabolism*
Kinetochores / metabolism*
Models, Biological*
Phosphorylation
Polo-Like Kinase 1
Protein Serine-Threonine Kinases / metabolism*
Proto-Oncogene Proteins / metabolism*

Substances

Cell Cycle Proteins
Proto-Oncogene Proteins
Protein Serine-Threonine Kinases