Development of wollastonite-poly(ethylmethacrylate co-vinylpyrrolidone) based materials for multifunctional devices

J Biomed Mater Res A. 2007 Jun 1;81(3):603-10. doi: 10.1002/jbm.a.30956.

Abstract

The manufacturing of a composite made of a synthetic bioactive ceramic, pseudowollastonite (psW), and a bioresorbable copolymer ethylmethacrylate-vinylpyrrolidone (EMA/VP) is presented in this article. psW porous blocks were produced by dipping an open porous polyurethane foam in a psW containing slurry. A 40/60 wt % EMA/VP monomers mixture was poured on the blocks, and free radical polymerization initiated by azobis(isobutyronitrile) at 50 degrees C. Disks of 1 mm height were obtained by cutting the composite with a diamond saw, and bioresorption and bioactivity of the specimens were tested by immersion of the disks into SBF. A ceramic/polymer weight ratio of 72/28, greater than the usually achievable ratio by polymeric solidification of slurries of monomers charged with a powdered solid component, has been obtained. The system is bioactive and does not change the pH of the medium during the degradation test.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry*
  • Calcium Compounds / chemistry*
  • Equipment and Supplies*
  • Hydrogen-Ion Concentration
  • Magnetic Resonance Spectroscopy
  • Methylmethacrylates / chemistry*
  • Microscopy, Electron, Scanning
  • Molecular Weight
  • Silicates / chemistry*
  • Solutions
  • Thermogravimetry
  • X-Ray Diffraction

Substances

  • Biocompatible Materials
  • Calcium Compounds
  • Methylmethacrylates
  • Silicates
  • Solutions
  • poly(ethylmethacrylate)
  • calcium silicate