Prognostic value of plasma L-lactate concentration measured cow-side with a portable clinical analyzer in Holstein dairy cattle with abomasal disorders

J Vet Intern Med. 2006 Nov-Dec;20(6):1463-70. doi: 10.1892/0891-6640(2006)20[1463:pvoplc]2.0.co;2.

Abstract

Background: L-Lactate has been used as a prognostic indicator for ill humans and animals. A portable analyzer that measures L-lactate could help veterinarians decide to proceed with correction of a displaced abomasum.

Hypotheses: The likelihood of a dairy cow with a displaced abomasum remaining in the herd can be predicted by lactate concentration and other variables.

Animals: Thirty-four healthy early-lactation dairy cows, and 131 cows with abomasal displacements (DA) presented to Cornell University, Ithaca, NY.

Methods: Plasma L-lactate was measured using a commercial analyzer (i-STAT). A cow had a positive outcome (PO) if she remained in the herd 30 days after surgical correction of the displaced abomasum and a negative outcome (NO) if she was culled or died in that time. A multivariable model with physical examination and clinicopathologic variables for predicting NO for cows with right-sided abomasal displacements was constructed.

Results: The median plasma L-lactate was 0.54 mM/L (interquartile range, 0.42-0.74) in healthy lactating Holstein cows. In cows with right-sided displaced abomasa, median plasma L-lactate concentrations were higher in cows with NO (5.88 mM/L) versus PO (3.23 mM/L) (P = .002). In a multivariable model, which identified chloride, heart rate, and L-lactate as the best fitting variables for cows with right-sided displacements, the probability of NO increased as L-lactate increased.

Conclusions and clinical importance: Plasma L-lactate concentration might be a useful predictor of productive outcomes in cows with right-sided abomasal disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abomasum*
  • Animals
  • Blood Chemical Analysis / instrumentation
  • Blood Chemical Analysis / veterinary*
  • Cattle
  • Cattle Diseases / blood
  • Cattle Diseases / diagnosis*
  • Cattle Diseases / surgery
  • Female
  • Lactates / blood*
  • Predictive Value of Tests
  • Prognosis
  • Stomach Diseases / blood
  • Stomach Diseases / diagnosis*
  • Stomach Diseases / surgery
  • Survival Analysis
  • Treatment Outcome

Substances

  • Lactates