Dysregulation of apoptotic death in the pathogenesis of virus-induced cytogenetic instability of blood lymphocytes

N V Ryazantseva; V V Novitskii; O B Zhukova; T T Radzivil; S L Mikheev; O E Chechina; A P Zima; B V Shilov

doi:10.1007/s10517-006-0233-x

Dysregulation of apoptotic death in the pathogenesis of virus-induced cytogenetic instability of blood lymphocytes

Bull Exp Biol Med. 2006 May;141(5):606-9. doi: 10.1007/s10517-006-0233-x.

Authors

N V Ryazantseva¹, V V Novitskii, O B Zhukova, T T Radzivil, S L Mikheev, O E Chechina, A P Zima, B V Shilov

Affiliation

¹ Siberian State Medical University, Tomsk. ryazan@mail.tomsknet.ru

PMID: 17181065
DOI: 10.1007/s10517-006-0233-x

Abstract

The cytogenetic status and activity of regulatory systems for stability of the cell genome were evaluated in patients with chronic viral persistence. Hepatitis B and C viruses damage the chromosome apparatus of peripheral blood lymphocytes. Cytogenetic instability of immunocompetent cells during chronic viral infection was associated with inhibition of DNA excision repair system and dysregulation of apoptosis in target cells.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Apoptosis / genetics
Apoptosis / physiology*
Chromosomal Instability / genetics*
Chromosome Aberrations*
Female
Fluorescein-5-isothiocyanate
Hepacivirus*
Hepatitis B virus*
Hepatitis, Viral, Human / physiopathology*
Hepatitis, Viral, Human / virology
Humans
Immunohistochemistry
Lymphocytes / physiology*
Male
Middle Aged
Scintillation Counting

Substances

Fluorescein-5-isothiocyanate