Abstract
Anaplasma marginale, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection, A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anaplasma marginale / genetics
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Anaplasma marginale / immunology*
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Anaplasmosis / immunology*
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Anaplasmosis / microbiology
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Anaplasmosis / transmission
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Animals
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Antigens, Bacterial / genetics
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Antigens, Bacterial / immunology*
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / immunology*
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Cattle
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Dermacentor / microbiology
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Immunity, Innate
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Male
Substances
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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msp2 protein, Anaplasma marginale