The sodium salt of diethyl 1H-pyrazole-3,5-dicarboxylate as an efficient amphiphilic receptor for dopamine and amphetamines. crystal structure and solution studies

J Am Chem Soc. 2006 Dec 27;128(51):16458-9. doi: 10.1021/ja064657h.

Abstract

The sodium salt of the diethyl 1H-pyrazole-3,5-dicarboxylate (2) of amphiphilic character is able to interact with (+)-amphetamine, (+)-methamphetamine, and dopamine, yielding stable complexes. Crystal structure of 2 with (+)-amphetamine leads to a very nice double helical supramolecular structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamines / chemistry*
  • Carboxylic Acids / chemistry*
  • Crystallization
  • Crystallography, X-Ray
  • Dopamine / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Pyrazoles / chemistry*
  • Salts / chemistry
  • Solutions / chemistry
  • Stereoisomerism
  • Water / chemistry

Substances

  • Amphetamines
  • Carboxylic Acids
  • Pyrazoles
  • Salts
  • Solutions
  • diethyl 1H-pyrazole-3,5-dicarboxylate
  • Water
  • Dopamine