Abstract
Enterostatin (APGPR) is a pentapeptide released from its precursor protein, procolipase. We found for the first time that enterostatin has memory-enhancing activity. Enterostatin enhanced memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice. The memory-enhancing activity of enterostatin was inhibited by pretreatment with lorglumide, an antagonist for cholecystokinin 1 (CCK1) receptor. However, enterostatin had no affinity for CCK receptors. These results suggest that enterostatin improves memory retention through CCK release.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Animals
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Avoidance Learning
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Colipases / administration & dosage
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Colipases / pharmacology*
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Colipases / physiology
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Enzyme Precursors
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Injections, Intraventricular
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Male
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Memory / drug effects*
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Memory / physiology
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Mice
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Proglumide / analogs & derivatives
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Proglumide / pharmacology
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Protein Precursors / administration & dosage
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Protein Precursors / pharmacology*
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Protein Precursors / physiology
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Receptor, Cholecystokinin A / antagonists & inhibitors
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Receptor, Cholecystokinin A / physiology
Substances
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Colipases
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Enzyme Precursors
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Protein Precursors
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Receptor, Cholecystokinin A
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procolipase
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Proglumide
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lorglumide