Enterostatin (APGPR) enhances memory consolidation in mice

Peptides. 2007 Mar;28(3):719-21. doi: 10.1016/j.peptides.2006.11.003. Epub 2006 Dec 18.

Abstract

Enterostatin (APGPR) is a pentapeptide released from its precursor protein, procolipase. We found for the first time that enterostatin has memory-enhancing activity. Enterostatin enhanced memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice. The memory-enhancing activity of enterostatin was inhibited by pretreatment with lorglumide, an antagonist for cholecystokinin 1 (CCK1) receptor. However, enterostatin had no affinity for CCK receptors. These results suggest that enterostatin improves memory retention through CCK release.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Avoidance Learning
  • Colipases / administration & dosage
  • Colipases / pharmacology*
  • Colipases / physiology
  • Enzyme Precursors
  • Injections, Intraventricular
  • Male
  • Memory / drug effects*
  • Memory / physiology
  • Mice
  • Proglumide / analogs & derivatives
  • Proglumide / pharmacology
  • Protein Precursors / administration & dosage
  • Protein Precursors / pharmacology*
  • Protein Precursors / physiology
  • Receptor, Cholecystokinin A / antagonists & inhibitors
  • Receptor, Cholecystokinin A / physiology

Substances

  • Colipases
  • Enzyme Precursors
  • Protein Precursors
  • Receptor, Cholecystokinin A
  • procolipase
  • Proglumide
  • lorglumide