The ins and outs of MHC class II proteins in dendritic cells

Immunity. 2006 Dec;25(6):857-9. doi: 10.1016/j.immuni.2006.11.007.

Abstract

One more mechanism for regulating surface expression of MHC class II proteins in dendritic cells (an important process that regulates both tolerance and immunity) has been uncovered, polyubiquitination of Lys225 in the intracytoplasmic region and subsequent endocytosis and proteolysis (Omura-Hoshino et al., 2006; van Neil et al., 2006; Shin et al., 2006).

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Histocompatibility Antigens Class II / immunology*
  • Histocompatibility Antigens Class II / metabolism*
  • Humans
  • Ubiquitin / metabolism

Substances

  • Histocompatibility Antigens Class II
  • Ubiquitin