ent-Abietane diterpenoids from Isodon rubescens var. rubescens

Phytochemistry. 2007 Mar;68(5):616-22. doi: 10.1016/j.phytochem.2006.11.007. Epub 2006 Dec 14.

Abstract

ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC(50) value of 0.91 microM against A549 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes / chemistry*
  • Abietanes / isolation & purification
  • Abietanes / toxicity
  • Antineoplastic Agents / toxicity
  • Cell Line, Tumor / drug effects
  • Cell Survival / drug effects*
  • Humans
  • Isodon / chemistry*
  • Isodon / toxicity
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Leaves / chemistry*

Substances

  • Abietanes
  • Antineoplastic Agents
  • Plant Extracts