Abstract
ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC(50) value of 0.91 microM against A549 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abietanes / chemistry*
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Abietanes / isolation & purification
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Abietanes / toxicity
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Antineoplastic Agents / toxicity
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Cell Line, Tumor / drug effects
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Cell Survival / drug effects*
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Humans
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Isodon / chemistry*
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Isodon / toxicity
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Leaves / chemistry*
Substances
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Abietanes
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Antineoplastic Agents
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Plant Extracts