Microwave-assisted synthesis of new polysubstituted dienaminoesters and their cyclization to 3-bromo-2(1H)-pyridinones

Jeff Adams; Alison Hardin; Filisaty Vounatsos

doi:10.1021/jo0618526

Microwave-assisted synthesis of new polysubstituted dienaminoesters and their cyclization to 3-bromo-2(1H)-pyridinones

J Org Chem. 2006 Dec 22;71(26):9895-8. doi: 10.1021/jo0618526.

Authors

Jeff Adams¹, Alison Hardin, Filisaty Vounatsos

Affiliation

¹ Chemistry Process Research and Development, Custom Synthesis Laboratory, Amgen Inc., Thousand Oaks, California 91320, USA.

PMID: 17168618
DOI: 10.1021/jo0618526

Abstract

A microwave-assisted, telescoped synthesis, involving a Michael-type addition followed by intramolecular cyclization, provides an effective entry to the polysubstituted 3-bromo-2(1H)-pyridinone core.

MeSH terms

Cyclization
Esters / chemical synthesis*
Esters / chemistry
Esters / radiation effects*
Microwaves*
Molecular Structure
Pyridones / chemical synthesis*
Pyridones / chemistry
Pyridones / radiation effects*
Stereoisomerism

Substances

Esters
Pyridones