Abstract
A study into the use of a chiral phase-transfer catalyst in conjunction with acetone cyanohydrin to effect the enantioselective formation of alpha-amino nitriles from alpha-amido sulfones is described. This novel catalytic asymmetric Strecker reaction is analyzed with regard to the possible mechanistic basis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbonates / chemistry
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Catalysis
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Molecular Structure
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Nitriles / chemical synthesis*
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Nitriles / chemistry
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Phase Transition
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Potassium / chemistry
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Stereoisomerism
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Sulfones / chemistry*
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Water / chemistry
Substances
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Carbonates
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Nitriles
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Sulfones
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cyanohydrin
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Water
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potassium carbonate
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Potassium