In this paper, discrepancies and reference inaccuracies in the paper (Grana et al., 2003) are pointed out. Specifically, it is demonstrated that the definitions of "lesion gradient" and "skin lesion gradient," widely used in a number of medical papers on computer analysis of pigmented skin lesions, are unambiguous, and that the "new algorithm for border description" described in the subject paper substantially relies on well-established concepts dating back over one decade ago.