Total synthesis of phorboxazole a. 1. Preparation of four subunits

Org Lett. 2006 Dec 21;8(26):6039-42. doi: 10.1021/ol062530r.

Abstract

[Structure: see text] Four subunits of the potent antitumor agent phorboxazole A were constructed; fragments C20-C32 and C9-C19 containing tetrahydropyrans A and B, respectively, were assembled using palladium-catalyzed intramolecular alkoxycarbonylation.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
  • Oxazoles / chemical synthesis*
  • Palladium / chemistry

Substances

  • Antineoplastic Agents
  • Heterocyclic Compounds, 4 or More Rings
  • Oxazoles
  • phorboxazole A
  • Palladium