Highly enantioselective transfer hydrogenation of fluoroalkyl ketones

Damjan Sterk; Michel Stephan; Barbara Mohar

doi:10.1021/ol062358r

Highly enantioselective transfer hydrogenation of fluoroalkyl ketones

Org Lett. 2006 Dec 21;8(26):5935-8. doi: 10.1021/ol062358r.

Authors

Damjan Sterk¹, Michel Stephan, Barbara Mohar

Affiliation

¹ Laboratory of Organic and Medicinal Chemistry, National Institute of Chemistry, Hajdrihova 19, SI-1001 Ljubljana, Slovenia.

PMID: 17165898
DOI: 10.1021/ol062358r

Abstract

[Structure: see text] The asymmetric transfer hydrogenation of fluoroalkyl ketones mediated by [Ru(eta6-arene)((S,S)-R2NSO2DPEN)] catalysts using HCO2H-Et3N afforded the corresponding alcohols with high ee's and in excellent yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hydrogen / chemistry*
Ketones / chemistry*
Stereoisomerism

Substances

Ketones
Hydrogen