Differential pulse cathodic voltammetric determination of floctafenine and metopimazine

J Pharm Biomed Anal. 2007 Mar 12;43(4):1535-9. doi: 10.1016/j.jpba.2006.11.006. Epub 2006 Dec 11.

Abstract

A simple, rapid and sensitive voltammetric method for the determination of floctafenine (FFN) and metopimazine (MPZ) was developed. Well-defined cathodic waves were obtained for both drugs in Britton-Robinson buffer pH 9.0 using the differential-pulse mode at the hanging mercury drop electrode (HMDE). The current-concentration relationship was found to be linear over the ranges 0.4-3.6 and 0.4-2.4 microg ml(-1) for FFN and MPZ, respectively. The quantification of the two drugs in their pharmaceutical formulations was carried out using the proposed voltammetric method and compared with spectrophotometric analysis data. The mechanisms of the electrode reactions for the two drugs were proposed.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry*
  • Antiemetics / chemistry*
  • Buffers
  • Electrochemistry / instrumentation
  • Electrochemistry / methods
  • Electrodes
  • Hydrogen-Ion Concentration
  • Isonipecotic Acids / chemistry*
  • Molecular Structure
  • Pharmaceutical Preparations / analysis
  • Sensitivity and Specificity
  • Spectrophotometry
  • Time Factors
  • ortho-Aminobenzoates / chemistry*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antiemetics
  • Buffers
  • Isonipecotic Acids
  • Pharmaceutical Preparations
  • ortho-Aminobenzoates
  • metopimazine
  • floctafenine