Abstract
Multidrug-resistance efflux pumps - in particular those belonging to the resistance-nodulation-cell-division (RND) family of transporters, with their unusually high degree of substrate promiscuity - significantly restrict the effectiveness of antibacterial therapy. Recent years have heralded remarkable insights into the structure and mechanisms of these fascinating molecular machines. Here, we review recent advances in the field and describe various approaches used in combating efflux-mediated resistance.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B / metabolism*
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Anti-Bacterial Agents / metabolism*
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Anti-Bacterial Agents / therapeutic use
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Bacteria / drug effects*
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Bacteria / metabolism*
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Bacterial Infections / drug therapy
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Bacterial Infections / microbiology
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Carrier Proteins / metabolism*
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Drug Resistance, Bacterial / physiology
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Humans
Substances
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ATP Binding Cassette Transporter, Subfamily B
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Anti-Bacterial Agents
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Carrier Proteins