Abstract
Polycyclic aromatic hydrocarbons (PAHs) are a class of genotoxic environmental contaminants. We have long been interested in determining the mechanisms by which PAHs induce genotoxicity. Although the metabolic activation of PAHs leading to biological activities has been well studied, the photo-induced activation pathway has seldom reported. In this paper, we review the study of photoirradiation of PAHs with UVA irradiation results in (i) cytotoxicity and DNA damage (ii) DNA single strand cleavage; (iii) formation of 8-hydroxy-2'-deoxyguanosine adduct (8-OHdG), and (iv) formation of lipid peroxidation. Evidence has been shown that these photobiological activities are mediated by reactive oxygen species (ROS).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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DNA Adducts / chemical synthesis
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DNA Adducts / radiation effects
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DNA Damage*
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DNA, Single-Stranded / drug effects
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DNA, Single-Stranded / metabolism
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DNA, Single-Stranded / radiation effects
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Environmental Pollutants / radiation effects
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Environmental Pollutants / toxicity
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Guanine / analogs & derivatives
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Guanine / chemical synthesis
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Light / adverse effects
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Lipid Peroxidation* / drug effects
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Lipid Peroxidation* / radiation effects
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Models, Biological
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Models, Theoretical
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Photochemistry
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Polycyclic Aromatic Hydrocarbons / chemical synthesis
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Polycyclic Aromatic Hydrocarbons / radiation effects*
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Polycyclic Aromatic Hydrocarbons / toxicity*
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Reactive Oxygen Species / chemical synthesis*
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Signal Transduction / radiation effects
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Ultraviolet Rays*
Substances
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DNA Adducts
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DNA, Single-Stranded
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Environmental Pollutants
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Polycyclic Aromatic Hydrocarbons
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Reactive Oxygen Species
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polycyclic aromatic hydrocarbons-DNA adduct
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8-hydroxyguanine
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Guanine