Three-dimensional structure of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum

Nobutada Tanaka; Masayuki Nakanishi; Yoshio Kusakabe; Katsura Shiraiwa; Saori Yabe; Yasutomo Ito; Yukio Kitade; Kazuo T Nakamura

doi:10.1093/nass/48.1.281

Three-dimensional structure of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum

Nucleic Acids Symp Ser (Oxf). 2004:(48):281-2. doi: 10.1093/nass/48.1.281.

Authors

Nobutada Tanaka¹, Masayuki Nakanishi, Yoshio Kusakabe, Katsura Shiraiwa, Saori Yabe, Yasutomo Ito, Yukio Kitade, Kazuo T Nakamura

Affiliation

¹ School of Pharmaceutical Sciences, Showa University, Tokyo 142-8555, Japan.

PMID: 17150588
DOI: 10.1093/nass/48.1.281

Abstract

Structural information of Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase (PfSAHH) has been expected to provide new-type chemotherapeutic agents against malaria. Here we report the crystal structure of PfSAHH. The present structure should provide opportunities to design potent and selective PfSAHH inhibitors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosylhomocysteinase / chemistry*
Animals
Crystallization
Crystallography, X-Ray
Plasmodium falciparum / enzymology*

Substances

Adenosylhomocysteinase