Structural stability and length of I-motif of G-quartet in DNA octaplex

Kenta Mitomi; Tanashaya Ciengshin; Jiro Kondo; Akio Takénaka

doi:10.1093/nass/48.1.121

Structural stability and length of I-motif of G-quartet in DNA octaplex

Nucleic Acids Symp Ser (Oxf). 2004:(48):121-2. doi: 10.1093/nass/48.1.121.

Authors

Kenta Mitomi¹, Tanashaya Ciengshin, Jiro Kondo, Akio Takénaka

Affiliation

¹ Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama 226-8501, Japan.

PMID: 17150508
DOI: 10.1093/nass/48.1.121

Abstract

To confirm that longer DNA strands with sequences gcGA[G](n)Agc can form an octaplex, X-ray analyses at n>1 have been performed. Several crystals of d(gcGA[G]2Agc) are obtained under different conditions. It has been found that the crystal obtained with cobalt hexamine suggests a hexaplex formation, while the crystal obtained with Mg2+ and Na+ ions suggests an octaplex formation.

MeSH terms

Base Sequence
Crystallography, X-Ray
DNA / chemistry*
DNA / genetics*
Hydrogen Bonding
Models, Molecular
Nucleic Acid Conformation*
Thermodynamics

Substances

DNA