Drug release from functionalized oligodeoxynucleotide by photo-induced electron transfer

Yukihiro Tachi; Arimichi Okazaki; Kazuhito Tanabe; Hiroshi Hatta; Sei-ichi Nishimoto

doi:10.1093/nass/48.1.79

Drug release from functionalized oligodeoxynucleotide by photo-induced electron transfer

Nucleic Acids Symp Ser (Oxf). 2004:(48):79-80. doi: 10.1093/nass/48.1.79.

Authors

Yukihiro Tachi¹, Arimichi Okazaki, Kazuhito Tanabe, Hiroshi Hatta, Sei-ichi Nishimoto

Affiliation

¹ Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, Japan.

PMID: 17150487
DOI: 10.1093/nass/48.1.79

Abstract

We synthesized a photoreactive hairpin-type oligodeoxynucleotide (P-ODN) possessing an o-nitrobenzyl chromophore and a triplet quencher of 1-aminonaphthalene. Photoirradiation of the hybrid of H-ODN with its complementary DNA led to release of drug in an efficient amount, while the photo-induced drug release was remarkably suppressed in the absence of complementary DNA.

MeSH terms

Base Sequence
Benzoic Acid
DNA, Complementary / radiation effects
Drug Delivery Systems / methods*
Electrons*
Light*
Molecular Sequence Data
Nucleic Acid Conformation / radiation effects
Oligodeoxyribonucleotides / chemistry*
Oligodeoxyribonucleotides / genetics
Oligodeoxyribonucleotides / radiation effects*

Substances

DNA, Complementary
Oligodeoxyribonucleotides
Benzoic Acid