The purpose of this investigation was to identify a deep-water running (DWR) style that most closely approximates terrestrial running, particularly relative to the lower extremities. Twenty intercollegiate distance runners (women, N = 12; men, N = 8) were videotaped from the right sagittal view while running on a treadmill (TR) and in deep water at 55-60% of their TR VO(2)max using 2 DWR styles: cross-country (CC) and high-knee (HK). Variables of interest were horizontal (X) and vertical (Y) displacement of the knee and ankle, stride rate (SR), VO(2), heart rate (HR), and rating of perceived exertion (RPE). Multivariate omnibus tests revealed statistically significant differences for RPE (p < 0.001). The post hoc pairwise comparisons revealed significant differences between TR and both DWR styles (p < 0.001). The kinematic variables multivariate omnibus tests were found to be statistically significant (p < 0.001 to p < 0.019). The post hoc pairwise comparisons revealed significant differences in SR (p < 0.001) between TR (1.25 +/- 0.08 Hz) and both DWR styles and also between the CC (0.81 +/- 0.08 Hz) and HK (1.14 +/- 0.10 Hz) styles of DWR. The CC style of DWR was found to be similar to TR with respect to linear ankle displacement, whereas the HK style was significantly different from TR in all comparisons made for ankle and knee displacement. The CC style of DWR is recommended as an adjunct to distance running training if the goal is to mimic the specificity of the ankle linear horizontal displacement of land-based running, but the SR will be slower at a comparable percentage of VO(2)max.