Adaptive allocation and failure saving in randomised clinical trials

J Biopharm Stat. 2006;16(6):817-29. doi: 10.1080/10543400600762947.

Abstract

In the present work, we develop a randomized two-treatment single period response adaptive design by combining two contrasting aspects (i.e., ethics and optimality), where optimality is defined in a meaningful way. We compare this rule with some of the existing rules by computing various performance measures of the rules.

MeSH terms

  • Algorithms
  • Depressive Disorder / drug therapy
  • Depressive Disorder / psychology
  • Fluoxetine / therapeutic use
  • Humans
  • Psychiatric Status Rating Scales
  • Randomized Controlled Trials as Topic / ethics
  • Randomized Controlled Trials as Topic / statistics & numerical data*
  • Research Design / statistics & numerical data
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Treatment Outcome

Substances

  • Serotonin Uptake Inhibitors
  • Fluoxetine