Abstract
In the present work, we develop a randomized two-treatment single period response adaptive design by combining two contrasting aspects (i.e., ethics and optimality), where optimality is defined in a meaningful way. We compare this rule with some of the existing rules by computing various performance measures of the rules.
MeSH terms
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Algorithms
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Depressive Disorder / drug therapy
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Depressive Disorder / psychology
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Fluoxetine / therapeutic use
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Humans
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Psychiatric Status Rating Scales
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Randomized Controlled Trials as Topic / ethics
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Randomized Controlled Trials as Topic / statistics & numerical data*
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Research Design / statistics & numerical data
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Selective Serotonin Reuptake Inhibitors / therapeutic use
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Treatment Outcome
Substances
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Serotonin Uptake Inhibitors
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Fluoxetine