Griseusin C, a novel quinone derivative from a marine-derived fungus Penicillium sp

Arch Pharm Res. 2006 Nov;29(11):942-5. doi: 10.1007/BF02969275.

Abstract

A novel quinone derivative, Griseusin C (1), along with a known quinone, Naphthoquinone C (2), was isolated from the lyophilized culture broth of the marine-derived fungus Penicillium sp. The structures were elucidated on the basis of extensive 1 D- and 2D-NMR, as well as HRESI-MS, spectroscopic analysis. The relative stereochemistries of the compounds were assessed by NOESY analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) / antagonists & inhibitors
  • Enzyme Inhibitors / pharmacology
  • Horseradish Peroxidase / antagonists & inhibitors
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Naphthoquinones / chemistry
  • Naphthoquinones / isolation & purification
  • Naphthoquinones / pharmacology
  • Penicillium / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Xanthine Oxidase / antagonists & inhibitors

Substances

  • Enzyme Inhibitors
  • Naphthoquinones
  • griseusin
  • 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
  • Horseradish Peroxidase
  • Xanthine Oxidase