Streptococcus pneumoniae pilus subunits protect mice against lethal challenge

Infect Immun. 2007 Feb;75(2):1059-62. doi: 10.1128/IAI.01400-06. Epub 2006 Dec 4.

Abstract

Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of intraperitoneal infection. Both active and passive immunization with recombinant pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype 4 strain TIGR4.

MeSH terms

  • Animals
  • Antibodies, Bacterial / blood
  • Antigens, Bacterial / administration & dosage
  • Antigens, Bacterial / immunology*
  • Bacteremia
  • Disease Models, Animal
  • Female
  • Fimbriae, Bacterial / immunology*
  • Immunization, Passive
  • Mice
  • Mice, Inbred BALB C
  • Pneumococcal Infections / prevention & control*
  • Pneumococcal Vaccines / immunology*
  • Streptococcus pneumoniae / immunology*
  • Survival Analysis
  • Vaccination
  • Vaccines, Subunit / immunology
  • Vaccines, Synthetic / immunology

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Pneumococcal Vaccines
  • Vaccines, Subunit
  • Vaccines, Synthetic