Abstract
Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of intraperitoneal infection. Both active and passive immunization with recombinant pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype 4 strain TIGR4.
MeSH terms
-
Animals
-
Antibodies, Bacterial / blood
-
Antigens, Bacterial / administration & dosage
-
Antigens, Bacterial / immunology*
-
Bacteremia
-
Disease Models, Animal
-
Female
-
Fimbriae, Bacterial / immunology*
-
Immunization, Passive
-
Mice
-
Mice, Inbred BALB C
-
Pneumococcal Infections / prevention & control*
-
Pneumococcal Vaccines / immunology*
-
Streptococcus pneumoniae / immunology*
-
Survival Analysis
-
Vaccination
-
Vaccines, Subunit / immunology
-
Vaccines, Synthetic / immunology
Substances
-
Antibodies, Bacterial
-
Antigens, Bacterial
-
Pneumococcal Vaccines
-
Vaccines, Subunit
-
Vaccines, Synthetic