Abstract
The ability of small hairpin RNAs (shRNAs) to inhibit hepatitis C virus internal ribosome entry site (HCV IRES)-dependent gene expression was investigated in cultured cells and a mouse model. The results indicate that shRNAs, delivered as naked RNA or expressed from vectors, may be effective agents for the control of HCV and related viruses.
MeSH terms
-
Animals
-
Antiviral Agents*
-
Cells, Cultured
-
Gene Expression
-
Genetic Therapy
-
Hepatitis C / genetics
-
Hepatitis C / therapy*
-
Hepatocytes
-
Humans
-
Mice
-
RNA, Small Interfering / administration & dosage
-
RNA, Small Interfering / pharmacology*
-
RNA, Small Interfering / therapeutic use
Substances
-
Antiviral Agents
-
RNA, Small Interfering