Inhibition of hepatitis C IRES-mediated gene expression by small hairpin RNAs in human hepatocytes and mice

Ann N Y Acad Sci. 2006 Oct:1082:52-5. doi: 10.1196/annals.1348.060.

Abstract

The ability of small hairpin RNAs (shRNAs) to inhibit hepatitis C virus internal ribosome entry site (HCV IRES)-dependent gene expression was investigated in cultured cells and a mouse model. The results indicate that shRNAs, delivered as naked RNA or expressed from vectors, may be effective agents for the control of HCV and related viruses.

MeSH terms

  • Animals
  • Antiviral Agents*
  • Cells, Cultured
  • Gene Expression
  • Genetic Therapy
  • Hepatitis C / genetics
  • Hepatitis C / therapy*
  • Hepatocytes
  • Humans
  • Mice
  • RNA, Small Interfering / administration & dosage
  • RNA, Small Interfering / pharmacology*
  • RNA, Small Interfering / therapeutic use

Substances

  • Antiviral Agents
  • RNA, Small Interfering