Emergence and dissemination of Enterobacteriaceae isolates producing CTX-M-1-like enzymes in Spain are associated with IncFII (CTX-M-15) and broad-host-range (CTX-M-1, -3, and -32) plasmids

Angela Novais; Rafael Cantón; Raquel Moreira; Luísa Peixe; Fernando Baquero; Teresa M Coque

doi:10.1128/AAC.01070-06

Emergence and dissemination of Enterobacteriaceae isolates producing CTX-M-1-like enzymes in Spain are associated with IncFII (CTX-M-15) and broad-host-range (CTX-M-1, -3, and -32) plasmids

Antimicrob Agents Chemother. 2007 Feb;51(2):796-9. doi: 10.1128/AAC.01070-06. Epub 2006 Dec 4.

Authors

Angela Novais¹, Rafael Cantón, Raquel Moreira, Luísa Peixe, Fernando Baquero, Teresa M Coque

Affiliation

¹ Servicio de Microbiología, Hospital Universitario Ramón y Cajal, IMSALUD, Carretera de Colmenar, km. 9.1, Madrid 28034, Spain.

Abstract

The spread of CTX-M-1-like enzymes in Spain is associated with particular plasmids of broad-host-range IncN (blaCTX-M-32, blaCTX-M-1), IncL/M (blaCTX-M-1), and IncA/C2 (blaCTX-M-3) or narrow-host-range IncFII (blaCTX-M-15). The identical genetic surroundings of blaCTX-M-32 and blaCTX-M-1 and their locations on related 40-kb IncN plasmids indicate the in vivo evolution of this element.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Resistance, Bacterial
Enterobacteriaceae / enzymology*
Enterobacteriaceae / genetics
Enterobacteriaceae / isolation & purification
Evolution, Molecular
Humans
Plasmids*
Spain
beta-Lactamases* / biosynthesis
beta-Lactamases* / genetics
beta-Lactamases* / metabolism

Substances

beta-lactamase CTX-M-15
beta-lactamase CTX-M-3
beta-lactamase TEM-3
beta-Lactamases
beta-lactamase CTX-M-32, E coli