Abstract
A series of proteins with cocaine esterase ability have been shown to hydrolyze acetylcholine with similar rate enhancements. Docking studies revealed that acetylcholine binds in a similar orientation as cocaine. These results suggest that acetylcholinesterase activity may be inherent to cocaine esterases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / chemistry*
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Acetylcholinesterase / immunology
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Acetylcholinesterase / metabolism
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Antibodies, Catalytic / immunology
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Antibodies, Catalytic / pharmacology
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Antibodies, Monoclonal / immunology
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Antibodies, Monoclonal / pharmacology
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Binding Sites
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Carboxylic Ester Hydrolases / chemistry*
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Carboxylic Ester Hydrolases / immunology
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Carboxylic Ester Hydrolases / metabolism
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Catalysis
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Cocaine / chemistry*
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Cocaine-Related Disorders / drug therapy
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Cocaine-Related Disorders / enzymology
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Crystallography
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Humans
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Hydrolysis
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Models, Molecular
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Substrate Specificity
Substances
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Antibodies, Catalytic
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Antibodies, Monoclonal
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Carboxylic Ester Hydrolases
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cocaine esterase
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Acetylcholinesterase
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Cocaine