Abstract
The influence of activators (Ca(2+)-channels stimulator BAY K 8644 and phospholipase C stimulator fMLP) and inhibitors (Ca(2+)-channels blocker verapamil and alpha 1-adrenoceptors blocker prazosin) of the polyphosphoinositide system on cardiomyocytes sarcolemma, was studied. The structural effects of the PPI modifiers seem to be one of the mechanisms of the PPI physiological activity at the membrane level.
Publication types
-
Comparative Study
-
English Abstract
MeSH terms
-
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / pharmacology
-
Animals
-
Cattle
-
Fluorescent Dyes
-
Heart / drug effects*
-
In Vitro Techniques
-
Myocardium / ultrastructure*
-
N-Formylmethionine Leucyl-Phenylalanine / pharmacology
-
Phosphatidylinositol Phosphates
-
Phosphatidylinositols / antagonists & inhibitors
-
Phosphatidylinositols / physiology*
-
Prazosin / pharmacology
-
Sarcolemma / drug effects*
-
Sarcolemma / ultrastructure
-
Verapamil / pharmacology
Substances
-
Fluorescent Dyes
-
Phosphatidylinositol Phosphates
-
Phosphatidylinositols
-
N-Formylmethionine Leucyl-Phenylalanine
-
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
-
Verapamil
-
Prazosin