Abstract
The effect of acute pretreatment with a single dose of simvastatin (1 mg/kg, i.v.; 30 min before ischemia) on renal dysfunction caused by ischemia-reperfusion (I/R) injury in the rat was investigated. I/R injury was induced by clamping both renal vascular pedicles for 45 min, followed by 4 h of reperfusion with saline (2 ml/kg per hour). Simvastatin significantly improved both parameters of glomerular and tubular dysfunction (e.g., creatinine levels and fractional excretion of Na(+), respectively) and especially improved the histological score, compared to control I/R-injured rats treated with saline or 10% DMSO only.
MeSH terms
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Animals
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Creatinine / blood
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Disease Models, Animal
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
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Injections, Intravenous
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Kidney / blood supply
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Kidney / drug effects*
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Kidney / pathology
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Male
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Rats
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Rats, Wistar
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Reperfusion Injury / blood
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Reperfusion Injury / pathology
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Reperfusion Injury / prevention & control*
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Reperfusion Injury / urine
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Simvastatin / administration & dosage
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Simvastatin / pharmacology*
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Simvastatin / therapeutic use
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Sodium / urine
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Urea / blood
Substances
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Urea
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Sodium
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Simvastatin
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Creatinine