High times for memory: cannabis disrupts temporal coordination among hippocampal neurons

Nat Neurosci. 2006 Dec;9(12):1461-3. doi: 10.1038/nn1206-1461.

Abstract

Exogenous cannabinoid receptor agonists impair hippocampus-dependent learning and decrease the power of hippocampal electroencephalographic activity. A new paper shows that cannabinoids desynchronize neuronal assemblies without affecting average firing rates, and that this effect correlates with memory deficits in individuals.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cannabinoid Receptor Modulators / pharmacology
  • Cannabinoids / pharmacology*
  • Cortical Synchronization / drug effects*
  • Hippocampus / cytology
  • Hippocampus / drug effects*
  • Humans
  • Memory / drug effects
  • Neurons / drug effects*
  • Receptors, Cannabinoid / classification
  • Receptors, Cannabinoid / drug effects
  • Receptors, Cannabinoid / physiology
  • Synaptic Transmission / drug effects*
  • Time Factors

Substances

  • Cannabinoid Receptor Modulators
  • Cannabinoids
  • Receptors, Cannabinoid