A simple track structure model of ion beam radiotherapy

Radiat Prot Dosimetry. 2006;122(1-4):471-4. doi: 10.1093/rpd/ncl471. Epub 2006 Nov 24.

Abstract

A simple radiotherapy ion beam calculation based on the cellular track structure model, using in vitro cell survival parameters fitted from recent experimental data, is presented. The calculation represents a single-fraction ion exposure (roughly corresponding to a 2 Gy fraction of megavolt X rays) and exploits concepts used in clinical radiotherapy, such as entrance, or 'skin' ion dose. The depth distribution of cells surviving their irradiation by a beam of 385 MeV amu(-1) carbon ions is calculated over the range of the stopping ions, as a sequence of track-segments, in the continuous slowing-down approximation. An interpretation of the 'clinical relative biological effectiveness' concept is suggested.

MeSH terms

  • Animals
  • Cell Survival / radiation effects
  • Computer Simulation
  • Heavy Ion Radiotherapy*
  • Humans
  • Linear Energy Transfer*
  • Models, Biological*
  • Neoplasms / physiopathology
  • Neoplasms / radiotherapy*
  • Radiometry / methods*
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted / methods*
  • Radiotherapy, Conformal / methods*
  • Scattering, Radiation