Abstract
Two new flavanones, remangiflavanones D and E (1 and 2), were isolated from an extract of the twigs, leaves, and flowers of Physena madagascariensis together with three known flavanones, remangiflavanones A-C (3-5), and (E)-N-feruloyltyramine (6). The structures of the new compounds 1 and 2 were established on the basis of one-dimensional and two-dimensional NMR spectroscopic data interpretation. All compounds were evaluated for their cytotoxicity in the A2780 human ovarian cancer cell line. Compound 5 was the most active with an IC50 value of 2.5 microg mL-1.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Caryophyllaceae / chemistry*
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Cell Line, Tumor
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Circular Dichroism
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Cytotoxins / chemistry
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Cytotoxins / isolation & purification*
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Cytotoxins / pharmacology
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Female
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Flavanones / chemistry
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Flavanones / isolation & purification*
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Flavanones / pharmacology
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Humans
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Inhibitory Concentration 50
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Madagascar
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Mass Spectrometry
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Ovarian Neoplasms / drug therapy
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Plant Components, Aerial / chemistry
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology
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Spectrophotometry, Ultraviolet
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Spectroscopy, Fourier Transform Infrared
Substances
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Antineoplastic Agents, Phytogenic
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Cytotoxins
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Flavanones
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Plant Extracts