High-dose ziprasidone-induced acute dystonia

Paul J Rosenfield; Ragy R Girgis; Roberto Gil

doi:10.1016/j.pnpbp.2006.10.005

High-dose ziprasidone-induced acute dystonia

Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):546-7. doi: 10.1016/j.pnpbp.2006.10.005. Epub 2006 Nov 22.

Authors

Paul J Rosenfield¹, Ragy R Girgis, Roberto Gil

Affiliation

¹ Department of Psychiatry, College of Physicians and Surgeons, Columbia University, and New York State Psychiatric Institute, 1051 Riverside Drive, Box 109, New York, NY 10032, USA.

PMID: 17123682
DOI: 10.1016/j.pnpbp.2006.10.005

Abstract

There are few clinical data describing the relative risks of extrapyramidal symptoms (EPS) at higher doses of ziprasidone (i.e., greater than 160 mg/day) when compared to lower doses. We report on a patient who displayed no EPS with ziprasidone 160 mg/day for several months, but did display marked, acute dystonic reactions on ziprasidone 240 mg/day. The observations from the present case indicate that high-dose, ziprasidone-induced acute dystonia may occur even if no such side effects have been experienced at doses up to and including 160 mg/day.

Publication types

Case Reports

MeSH terms

Adult
Antipsychotic Agents / adverse effects*
Dose-Response Relationship, Drug
Dystonia / chemically induced*
Female
Humans
Piperazines / adverse effects*
Schizophrenia / drug therapy
Thiazoles / adverse effects*

Substances

Antipsychotic Agents
Piperazines
Thiazoles
ziprasidone