Occupational exposure to blood and other potentially infectious body fluids places health care workers at risk for acquisition of bloodborne pathogens, including the human immunodeficiency virus (HIV). Utilizing appropriate techniques, personal protective equipment, and safer "sharp" technology can minimize the risk of these exposures. When exposure does occur, immediate evaluation and initiation of post-exposure prophylaxis, when indicated. can substantially reduce the risk of transmission of HIV. In this article, the basic concepts of exposure prevention and management are reviewed.