Influence of pravastatin on carotid artery structure and function in dyslipidemic HIV-infected patients receiving antiretroviral therapy

AIDS. 2006 Nov 28;20(18):2395-8. doi: 10.1097/QAD.0b013e32801120e3.

Abstract

Forty-two pravastatin-treated HIV-positive patients and 42 sex, age, and smoking status-matched hypercholesterolemic HIV-positive patients not under lipid-lowering treatment were compared for differences in intima-media thickness (IMT) of the common carotid artery (CCA) and aortic stiffness. Pravastatin had no influence on carotid artery structure and function, or aortic stiffness. Age and body mass index were independent determinants of IMT of the CCA. Mean arterial pressure, age, duration of HIV infection and protease inhibitor exposure determined aortic stiffness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Anticholesteremic Agents / therapeutic use*
  • Antiretroviral Therapy, Highly Active / methods
  • Aorta / drug effects
  • Aorta / pathology
  • Blood Pressure / physiology
  • Body Mass Index
  • Carotid Artery, Common / drug effects*
  • Carotid Artery, Common / pathology
  • Female
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • HIV Infections / pathology
  • Humans
  • Hypercholesterolemia / complications
  • Hypercholesterolemia / drug therapy*
  • Hypercholesterolemia / pathology
  • Male
  • Middle Aged
  • Pravastatin / therapeutic use*
  • Time Factors
  • Treatment Outcome
  • Tunica Intima / drug effects
  • Tunica Intima / pathology

Substances

  • Anticholesteremic Agents
  • Pravastatin