Derepression of excision of integrative and potentially conjugative elements from Streptococcus thermophilus by DNA damage response: implication of a cI-related repressor

Xavier Bellanger; Catherine Morel; Bernard Decaris; Gérard Guédon

doi:10.1128/JB.01125-06

Derepression of excision of integrative and potentially conjugative elements from Streptococcus thermophilus by DNA damage response: implication of a cI-related repressor

J Bacteriol. 2007 Feb;189(4):1478-81. doi: 10.1128/JB.01125-06. Epub 2006 Nov 17.

Authors

Xavier Bellanger¹, Catherine Morel, Bernard Decaris, Gérard Guédon

Affiliation

¹ Laboratoire de Génétique et Microbiologie UMR1128, INRA, Faculté des Sciences et Techniques, Université Henri Poincaré Nancy 1, 1 Bd des Aiguillettes, BP239, F-54506 Vandoeuvre-lès-Nancy, France.

Abstract

A DNA-damaging agent, mitomycin C, derepresses the site-specific excision of two integrative and potentially conjugative elements from Streptococcus thermophilus, ICESt1 and ICESt3. The regulation pathway involves a repressor related to phage lambda cI repressor. It could also involve a putative regulator related to another type of phage repressors, the "cI-like" repressors.

MeSH terms

DNA Damage*
DNA-Binding Proteins / metabolism*
Gene Expression Regulation, Bacterial / physiology*
Mitomycin / pharmacology
Nucleic Acid Synthesis Inhibitors / pharmacology
Repressor Proteins / metabolism*
Streptococcus thermophilus / genetics*
Streptococcus thermophilus / metabolism*
Viral Proteins / metabolism*
Viral Regulatory and Accessory Proteins

Substances

DNA-Binding Proteins
Nucleic Acid Synthesis Inhibitors
Repressor Proteins
Viral Proteins
Viral Regulatory and Accessory Proteins
phage repressor proteins
Mitomycin