Synthesis and characterization of xylan-coated magnetite microparticles

Int J Pharm. 2007 Apr 4;334(1-2):42-7. doi: 10.1016/j.ijpharm.2006.10.019. Epub 2006 Oct 13.

Abstract

This work evaluates an experimental set-up to coat superparamagnetic particles in order to protect them from gastric dissolution. First, magnetic particles were produced by coprecipitation of iron salts in alkaline medium. Afterwards, an emulsification/cross-linking reaction was carried out in order to produce magnetic polymeric particles. The sample characterization was performed by X-ray powder diffraction, laser scattering particle size analysis, optical microscopy, thermogravimetric analysis and vibrating sample magnetometry. In vitro dissolution tests at gastric pH were evaluated for both magnetic particles and magnetic polymeric particles. The characterization data have demonstrated the feasibility of the presented method to coat, and protect magnetite particles from gastric dissolution. Such systems may be very promising for oral administration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Delayed-Action Preparations
  • Drug Delivery Systems
  • Ferrosoferric Oxide / chemical synthesis
  • Ferrosoferric Oxide / chemistry*
  • Hydrogen-Ion Concentration
  • Lasers
  • Magnetics*
  • Microscopy, Electron, Scanning
  • Particle Size
  • Polymers / chemistry*
  • Scattering, Radiation
  • Solubility
  • Thermogravimetry
  • X-Ray Diffraction
  • Xylans / chemistry*
  • Zea mays

Substances

  • Delayed-Action Preparations
  • Polymers
  • Xylans
  • Ferrosoferric Oxide