Central nervous system toxicity from cancer therapies

David Schiff; Patrick Wen

doi:10.1016/j.hoc.2006.09.004

Central nervous system toxicity from cancer therapies

Hematol Oncol Clin North Am. 2006 Dec;20(6):1377-98. doi: 10.1016/j.hoc.2006.09.004.

Authors

David Schiff¹, Patrick Wen

Affiliation

¹ Neuro-Oncology Center, University of Virginia, Box 800432, Charlottesville, VA 22908-0432, USA. ds4jd@virginia.edu

PMID: 17113469
DOI: 10.1016/j.hoc.2006.09.004

Abstract

The central nervous system (CNS) is an organ with a unique profile of vulnerability to antineoplastic treatments. In many cases, CNS neurotoxicity is the dose-limiting side effect of treatment for systemic and CNS neoplasms. Novel methods of delivering radiation and chemotherapy agents have led to recognition of new forms of CNS neurotoxicity. In this article, the authors review the most important CNS toxicities of cancer treatment.

MeSH terms

Antineoplastic Agents / adverse effects*
Central Nervous System* / drug effects
Central Nervous System* / radiation effects
Humans
Neurotoxicity Syndromes / etiology*
Radiotherapy / adverse effects*

Substances

Antineoplastic Agents