Glioma oncogenesis and animal models of glioma formation

Yelena Lyustikman; Andrew B Lassman

doi:10.1016/j.hoc.2006.09.005

Glioma oncogenesis and animal models of glioma formation

Hematol Oncol Clin North Am. 2006 Dec;20(6):1193-214. doi: 10.1016/j.hoc.2006.09.005.

Authors

Yelena Lyustikman¹, Andrew B Lassman

Affiliation

¹ Department of Cancer Biology, Memorial Sloan-Kettering Cancer Center, 408 East 69th Street, Z1319, New York, NY 10021, USA.

PMID: 17113459
DOI: 10.1016/j.hoc.2006.09.005

Abstract

Recent advances in animal models have improved our understanding of the pathway abnormalities driving glioma growth. This article reviews key molecular abnormalities that have been modeled in mice, and describes major tumor modeling techniques along with examples of astrocytoma and oligodendroglioma models. Animal models are important not only for the testing of novel therapeutics but also as a means to understand the molecular explanations for treatment success and failure in humans.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain Neoplasms* / genetics
Brain Neoplasms* / metabolism
Brain Neoplasms* / pathology
Cell Cycle
Glioma* / genetics
Glioma* / metabolism
Glioma* / pathology
Intercellular Signaling Peptides and Proteins / metabolism
Mice
Receptor Protein-Tyrosine Kinases / metabolism
Signal Transduction
Xenograft Model Antitumor Assays

Substances

Intercellular Signaling Peptides and Proteins
Receptor Protein-Tyrosine Kinases