Increased postprandial lipemia or elevated levels of triglyceride-rich remnant lipoproteins in fasting plasma are associated with increased risk of coronary artery disease. Despite many studies showing that postprandial triglyceride-rich lipoproteins play a central role in the pathogenesis of atherosclerosis, suitably standardized methods to measure postprandial lipemia or remnant lipoproteins in the clinical setting are lacking. This approach for cardiovascular risk assessment is confined to research laboratories and for the time being is not a standard procedure in clinical practice.