Influence of epicardial adipose tissue and adipocytokine levels on cardiac abnormalities in visceral obesity

Int J Cardiol. 2007 Sep 14;121(1):132-4. doi: 10.1016/j.ijcard.2006.08.061. Epub 2006 Nov 13.

Abstract

Adipocytokine levels and visceral adipose tissue (VAT) seem to be associated with some cardiac abnormalities and a role of visceral fat in predisposing to cardiac dysfunction, possibly through a low-grade state of inflammation, has been demonstrated. In this study we firstly show that elevated levels of both monocyte chemoattractant protein 1 (MCP-1) and soluble IL-6 receptor/interleukin-6 (sIL-6R/IL-6) complex are closely correlated with epicardial fat thickness.

Publication types

  • Letter

MeSH terms

  • Adipose Tissue / diagnostic imaging*
  • Adult
  • Case-Control Studies
  • Chemokine CCL2 / blood*
  • Female
  • Heart Septum / diagnostic imaging
  • Heart Ventricles / diagnostic imaging
  • Humans
  • Interleukin-6 / blood*
  • Obesity / complications*
  • Pericardium / diagnostic imaging*
  • Receptors, Interleukin-6 / blood*
  • Regression Analysis
  • Ultrasonography

Substances

  • Chemokine CCL2
  • Interleukin-6
  • Receptors, Interleukin-6