Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography

Opt Lett. 2006 Dec 1;31(23):3459-61. doi: 10.1364/ol.31.003459.

Abstract

Co-registered optical coherence tomography (OCT) and video microscopy of the rat somatosensory cortex were acquired simultaneously through a thinned skull during forepaw electrical stimulation. Fractional signal change measured by OCT revealed a functional signal time course corresponding to the hemodynamic signal measurement made with video microscopy. OCT can provide high-resolution, cross-sectional images of functional neurovascular activation and may offer a new tool for basic neuroscience research in the important rat cerebral cortex model.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Brain Mapping / methods*
  • Cerebral Cortex / physiology*
  • Equipment Design
  • Equipment Failure Analysis
  • Image Interpretation, Computer-Assisted / instrumentation*
  • Image Interpretation, Computer-Assisted / methods
  • Microscopy, Video / instrumentation*
  • Microscopy, Video / methods
  • Rats
  • Tomography, Optical Coherence / instrumentation*
  • Tomography, Optical Coherence / methods