Disseminated Histoplasmosis is a severe and often-fatal opportunistic infection when left untreated among patients with AIDS. Occurring in 3-5 percent of patients with AIDS living in the areas of endemicity, this infection should be suspected in patients with a CD4 cell count of <150 cells/microL presenting with non-specific clinical signs such as fever, weight loss, and lymphadenopathy. We report our experience to increase awareness of the clinical spectrum of disseminated histoplasmosis and its similarity to other infections and malignancies and update the reader on recommended therapeutic modalities.